Abstract
Alpha-synuclein is a 140-amino-acid protein coded by SNCA gene and is mainly found in presynaptic terminals of dopaminergic neurons, typically in a monomeric state. Structurally, the protein is divided into three domains: N-terminal, amphipathic; central domain (NAC), hydrophobic; lastly, C-terminal, the main target of post-translational modifications. In synucleinopathies, such as Parkin…