Currently, I am a dedicated researcher pursuing a master's degree in the field of Genetic Biology at the University of São Paulo (USP). My research focus is on quantifying allele-specific expression of the 3 and 4 variants of the APOE gene in African and European ancestries.I began my academic journey at the Federal University of São Carlos (UFSCar), where I obtained a bachelor's degree in Biotechnology with a GPA of 8.01/10. During my undergraduate studies, I conducted a research project focused on validating molecular markers in peppers (Capsicum spp.), investigating their relationship with disease resistance and pungency.Throughout these experiences, I have developed solid skills in molecular methods and data analysis. I am committed to genetics and continuously improving my understanding in the field of neurogenetics. My goal is to contribute to significant progress in the field and to give back to society the benefits derived from this research. (Source: Lattes Curriculum)
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The APOE gene is identified as a major risk factor for late onset Alzheimer's disease and has three alleles, µ2, µ3 and µ4, related to two non-synonymous substitutions. The presence of the µ4 allele confers an increased risk for the disease in a dose dependent manner (odds ratio 12.9 for homozygous individuals and between 3.2 and 4.2 for heterozygous individuals). The most prevalent form …
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