Abstract
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease that causes destruction of motor neurons, both superior (SMN) and inferior (IMN), and that causes progressive paralysis of the somatic muscles. The disease is presented in two forms: sporadic (sALS), more frequent, around 90% of cases; and familial (fALS), 5-10% of cases. Regarding fALS, several genetic alterations …