CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Assistant Professor at the Department of Cell and Molecular Biology and Pathogenic Bioagents (FMRP-USP). Postdoctoral fellow at the St. Jude Children's Research Hospital (Memphis, TN, USA) (2014-2017) and FMRP-USP (2012-2014). B. S. in Biological Sciences from the University of Brasília (2003-2007) and Ph.D. in Cell and Molecular Biology from FMRP/USP (2007-2012). Current research interests are focused in Signaling in Innate Immunity, with emphasis on the molecular mechanisms of regulation of the innate immune response and its effects on the pathogenesis of inflammatory diseases and cancer, as well as on the host-pathogen interaction (Source: Lattes Curriculum)
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Autophagy is pivotal for cell homeostasis upon environmental stress and thus considered a promising therapeutic target for different pathologies. However, the role of autophagic components in diverse cell processes adds complexity to this goal. LC3-associates phagocytosis is one such processes, where the direct recruitment of components of autophagic machinery to the phagosome membrane re…
To restrain pathogen growth and to tolerate the negative impact of infection in host fitness are both fundamental requirements to survive an infectious disease. Macrophages are a determinant component of innate immunity during infection, not only to identify, trigger immune responses and eliminate the pathogen but also to restrain the inflammatory response and reduce immunopathology. In t…
The elimination of apoptotic cells (efferocytosis) is an essential mechanism of innate immunity to suppress potential pro-inflammatory responses in different tissues of the body. During efferocytosis, the LC3-associated phagocytosis (LAP) pathway is induced in macrophages, recruiting canonical autophagy components and specific components of the LAP pathway to conjugate the LC3 protein on …
Surviving an infection relies both in the capacity to detect and eliminate pathogens (resistance) and in the host adaptation to withstand the damaged caused by the virulence of the invading organism and by the host immune cells (tolerance or resilience). Tolerance induction is a multifaceted process that is still loosely defined, but that promotes maintenance of tissue barrier, downregula…
Long COVID is a disease characterized by the persistence of symptoms after the acute phase of COVID-19, lasting for weeks, months, or even years. Recent studies from our group have shown that thromboinflammatory mechanisms present in COVID-19, such as platelet activation and hyperresponsiveness, persist during long COVID following a severe case. However, none have demonstrated that these …
The process of efferocytosis, which involves the efficient removal, processing, and degradation of dead cells, is crucial for promoting tissue renewal and protecting against complications caused by excessive tissue damage accumulation. In general contexts, macrophages play an important role in phagocytosis and the elimination of these apoptotic cells. On the other hand, efferocytosis comb…
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Clearance of dying cells is a pivotal function of the immune system. During the phagocytosis of apoptotic cells (efferocytosis), some components of the autophagy machinery can be directly recruited to the phagosome membrane. This recruitment catalyzes the lipidation of proteins from the LC3-GABARAP family onto phosphatidylethanolamine and phosphatidylserine residues on the phagosome membr…
The non-canonical pathway of autophagy known as LC3-associated phagocytosis (LAP) is a key cellular process that regulates the responses of innate immune cells, controlling the balance of inflammation, and innate responses that promote tissue protection and repair. LAP, an example of a CASM (Conjugation of ATG8 to Endolysosomal Single Membranes) event, utilizes some, but not all, componen…
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| 3 / 3 | Ongoing scholarships in Brazil |
| 17 / 16 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 25 / 24 | All research grants and scholarships |
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