Abstract
The regulation of bacterial infectious processes, such as biofilm formation, is modulated by the intracellular levels of the second messenger cyclic bis-(3',5')-diguanosine monophosphate (c-di-GMP). The synthesis and degradation of c-di-GMP are coordinated by the antagonistic enzymatic activities of diguanylate cyclases (DGCs), which contain the GGDEF domain, and phosphodiesterases (PDEs)…