Abstract
DNA damage signalling and repair are regulated by a variety of post-translational modifications, including ubiquitination and ADP-ribosylation. We have previously identified the ADP-ribosyl transferase PARP9 and the ubiquitin ligase DTX3L in an in vitro screen for factors that bind to ADP-ribosylated Histone H2B, which is a PARP3 catalysed modification induced by DNA damage. Here, we will…