, acting on the following subjects: macrófagos associados a tumor, carcinoma de células escamosas de cabeça e pescoço, microambiente tumoral and técnicas de cultura de células em três dimensões. (Source: Lattes Curriculum)
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Pirfenidone is an anti-fibrotic drug clinically used in the treatment of idiopathic pulmonary fibrosis (IPF). It's mechanism of action is still not completely known, but many of its biological effects interfere with the biology of activated fibroblasts in IPF's chronic inflammation microenvironment, and considering the phenotypical and biological similarity between these activated fibrobl…
Leukocyte infiltration in head and neck squamous cell carcinoma (HNSCC) is associated with prognosis and response to treatment. This association is complex and may be positive (i.e., improved prognosis and response to treatment) or negative (i.e., worse prognosis and poor response to treatment) depending on the intensity of the immune cell infiltrate, of its composition and phenotype.The …
Head and neck squamous cell carcinoma (HNSCC) is the eighth most common cancer worldwide, with a 5-year survival rate of less than 50% in advanced cases. Macrophages are antigen-presenting cells and their profile of inflammatory cytokine secretion is determined by stimuli present in the microenvironment. Macrophages are present in large numbers inside solid tumors (TAMs, tumor-associated …
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