CV Lattes
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Fundação Pio XII (FP). Hospital do Câncer de Barretos (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Science - Medical Modality from Centro Universitário Barão de Mauá, Master's and Doctorate in Sciences from Faculdade de Ciências Farmacêuticas de Ribeirão Preto - USP. She did postdoctoral work at the University of Miami, Interdisciplinary Stem Cell Institute-Miami, USA. She is currently a Researcher at the Molecular Oncology Research Center of the Pio XII-Hospital de Câncer de Barretos (HCB), Young Researcher at FAPESP, professor and advisor of the Graduate Program at the Institute of Teaching and Research at HCB. Member of the Research Ethics Committee (CEP) and coordinator of the Animal Use Ethics Committee (CEUA) and the Commission for the Management of Scholarships and Research (CGBP) of the same institution. She has experience in the areas of Genetics and Molecular Biology, acting mainly in the search for biomarkers for pediatric tumors (microRNAs, mutations, DNA methylation) and in in vitro and in vivo models for the analysis of therapeutic response, acting in the investigation of mechanisms related to the epithelial-mesenchymal transition (EMT). (Source: Lattes Curriculum)
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Germ cell tumors (GCTs) are benign and malignant neoplasms derived from primordial germ cells. The treatment for these tumors includes surgery and chemotherapy, with cisplatin being one of the most widely used chemotherapeutic agents. Cisplatin binds to DNA, altering its structure and preventing its duplication and transcription, leading to cell death through apoptosis. However, the resis…
Cancer is one of the leading causes of death, particularly among children, adolescents, and young adults, with germ cell tumors (GCTs) being common in this group. Despite the good cure rate, the incidence of GCTs is increasing, accounting for around 10% of diagnoses in adolescents. These tumors arise from totipotent germ cells and can manifest in various regions of the body, including the…
Germ cell tumors (GCTs) are neoplasms that can occur in the gonads or extragonadal sites, with different histological subtypes that influence prognosis and treatment. Diagnosis is based on clinical data, tumor markers, and histopathological classification, and treatment for these tumors includes surgery and chemotherapy. However, the acquisition of a malignant phenotype is associated with…
(Only some records are available in English at this moment)
Germ cell tumors (GCTs) are derived from primordial germ cells and occur at both gonadaland extragonadal sites. They present great histological heterogeneity, and are classified into two main types: seminomas and non-seminomas. The diagnosis is established by correlating theclinical picture, typical location, imaging tests and biological markers. Treatment is based on strategies that incl…
The epithelial-mesenchymal transition (EMT) is characterized by loss of expression of epithelial cell markers and acquisition of mesenchymal markers, as well as gain of invasive and migratory cell properties. This transition can be induced by different transcription factors, including Snail and Slug. Once these transcription factors are activated, the E-cadherin gene transcription is inhi…
(Only some records are available in English at this moment)
Germ cell tumors (GCTs) are complex neoplasms with varying histological subtypes and clinical characteristics that present significant treatment challenges, particularly in pediatric cases and when exhibiting resistance to standard therapies like cisplatin. This project aims to investigate the role of Methionine Sulfoxide Reductase A (MSRA) in GCT pathogenesis, focusing on its expression …
Pediatric germ cell tumors (GCTs) are rare and account for 3.3% of malignant tumors in children. GCTs are characterized as benign or malignant neoplasms and can occur in gonadal or extragonadal sites. They are classified histologically as seminoma, dysgerminoma, yolk sac tumor, embryonal carcinoma, choriocarcinoma, mixed tumors, and mature and immature teratoma. Because GCTs are heterogen…
| 4 / 4 | Ongoing scholarships in Brazil |
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