Abstract
Anaplastic thyroid cancer (ATC) is the most aggressive tumor of the endocrine system, displaying a mean survival of 6 months and refractoriness to radioiodine therapy due to the loss of absence of thyroid differentiation and iodine metabolism genes expression. ATC oncogenesis is related to mutation in genes such as TP53, TERT and genes of the MAPK proliferative pathway. Moreover, the over…