Abstract
In paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Latin America, previous studies have revealed that host immunity is strongly regulated by various suppressive mechanisms mediated by plasmacytoid dendritic cells, the enzyme indoleamine 2,3-dioxygenase (IDO1), regulatory T cells, as well as negative co-stimulatory molecules such as CTLA-4 and PD-1. Immunotherapy with …