Manoela Osorio Reis Sales in research grants and scholarships supported by FAPESP.
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Previous results in our laboratory demonstrated a spleen-liver axis regulates TNF production in the bacterial lipopolysaccharide (LPS) induced systemic inflammation model in rats. Our proposal is that humoral signals released by spleen macrophages (which may include leukotriene B4) reach the liver via the bloodstream, where they interact with the liver's resident macrophages (Kupffer cell…
Cyclooxygenases (COX) are key enzymes in the biosynthesis of lipid mediators that play key roles in inflammation, especially the inducible isoform, called COX-2. The "constitutive" isoform, called COX-1, is seen asan enzyme of importance for "housekeeping" functions, with no role in inflammation.Recent evidence challenges this paradigm by revealing that COX-1 can also beimportant in infla…
| 2 / 2 | Completed scholarships in Brazil |
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