I hold a Bachelor's degree in Biomedicine from the Municipal University of São Caetano do Sul (USCS), having graduated in 2023 with a specialization in **Clinical Analysis and Molecular Biology**. Currently, I am pursuing a Master's degree in Biosystems at the Federal University of ABC (UFABC).During my undergraduate studies at USCS, I developed strong competencies in clinical analysis and molecular biology, applying this knowledge to laboratory diagnostics and scientific research. In 2023, I participated in a scientific initiation project supported by FAPESP, titled "Effect of p-cresyl sulfate on the components of purinergic signaling in the aorta of mice." I presented the findings of this project at major conferences, including the Symposium of the Brazilian Society for Cell Biology in 2024, the Brazilian Symposium on Cardiovascular Physiology in 2024, the XII Meeting of the Brazilian Purine Club in 2023, and the 3rd Biotechnology Week at UFABC.Currently, in the Master's in Biosystems program at UFABC, I am developing a research project, also supported by FAPESP, which continues my scientific initiation research. My current study explores the effects of the uremic toxin p-cresyl sulfate in a model of acute kidney injury by ischemia and reperfusion. This involves investigating the induced vascular alterations and evaluating the effects on purinergic signaling in the aorta of mice, using **molecular biology and bioinformatics techniques** to better understand the mechanism and interaction of this toxin. (Source: Lattes Curriculum)
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Acute kidney injury (AKI) is a sudden reduction or loss of kidney function that persists for up to 3 months and can be caused by various stimuli, such as ischemia and reperfusion injury (IR) and/or accumulation of uremic toxins (UT) such as p-cresyl sulfate (PCS). IR injury is the main cause of AKI as it is associated with necrosis of renal tubular endothelial cells, in situ and systemic …
Uremic toxins are organic solutes resulting from the fermentation of proteins from the diet and from the action of bacterial enzymes present in the gut microbiota. In the liver, the uremic toxin p-cresol is sulfated to form p-cresyl sulfate (PCS), which is excreted in the urine or feces under normal conditions. In dialysis patients, the serum concentration of PCS is 17 times higher than i…
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