Abstract
Cockayne Syndrome (CS) is a genetic neurodegenerative disease related to the impairment of the transcription-coupled repair sub-pathway (TCR-NER). The CSB protein acts directly on this repair subpathway and, therefore, CSB mutant cells are more sensitive to agents that cause DNA damage. The greater sensitivity of these cells to UV light, an agent that damage DNA, is well known, however, e…