Abstract
The RNA exosome is a ribonucleolytic complex formed by the association of differentsubunits. Because of its exoribonuclease 3'à5' catalytic activity, the exosome controls thelevels of all classes of RNAs, regulating the chromatin structure, gene expression, celldifferentiation and ribosome biogenesis. In this context, this RNase has been the main focus ofresearch in our laboratory. The ex…