Abstract
Lytic polysaccharide monooxygenases (LPMOs) are copper-dependent enzymes that perform an oxidative cleavage of glycosidic bonds. The uncommon and remarkable LPMOs' active site is composed of a single copper atom coordinated by three nitrogen ligands, a structural motif known as histidine brace. The nitrogen ligands are provided by the amino group and side chain of an N-terminal His, and a…