Abstract
Genetic defects in nucleotide excision repair (NER) result in syndromes whose patients have a high frequency of cancer and/or symptoms related to premature aging and neurodegeneration. In the case of mutations in the ERCC2/XPD gene, for example, mutations can lead to different pathologies, such as Xeroderma Pigmentosum (XP), Cockayne syndrome (CS) and Trichothiodystrophy (TTD), in which t…