Abstract
Tbx21/T-bet is a transcription factor of the T-box binding domain protein family that was originally described in CD4 T cells and later in T CD8, NK, NKT and ILC1 cells, as being responsible for the transactivation of the Interferon (IFN)y gene, for Th1-type response maintenance. T-bet represses Gata3 and RoryT in helper T lymphocytes and induces IgG2c expression on B lymphocytes, all of …