Abstract
Somatic mutations in genes responsible for epigenetic modulation seem to occur years before the diagnosis of acute myeloid leukemia (AML). Recently, the role of ascorbic acid (vitamin C) in regulating the activity of TET2 (ten-eleven-translocation 2), an important enzyme that catalyzes the hydroxylation of 5-methylcytosine, whose gene is frequently mutated in aging and myeloid neoplasms, …