CV Lattes
ORCID
Abstract
RAS proteins are small GTPases that regulate a number of signaling pathways, including the mitogen-activated protein kinase (MAPK) pathway. To perform this function, RAS proteins must associate with the plasma membrane. All RAS isoforms (HRAS, NRAS and, KRAS) are post-translationally modified at a C-terminal CaaX motif to gain affinity for cell membranes. Prominent among these post-transl…