Bachelor's degree in Biochemistry from the Federal University of Viçosa, Master of Science (Biochemistry) from the Ribeirão Preto Medical School at the University of São Paulo (FMRP/USP), applying solid-phase peptide synthesis in immunochemical studies. PhD in Science (Biochemistry) from FMRP/USP, focusing on proteomics combined with mass spectrometry, molecular biology, and cell biology to study protein-protein interactions in the Ubiquitin-Proteasome System in mammalian cells. Postdoctoral researcher under a BEPE-FAPESP fellowship at the University of Cambridge, supervised by Dr. Heike Laman, biochemically characterizing E3 ligases involved in Cancer and Parkinsons Disease (Fbxo7/PARK15 and Fbxl17). I was a professor for nearly 10 years in the Department of Genetics and Evolution at the Federal University of São Carlos, where I was responsible for courses in Metabolic Biochemistry. Father of two daughters (Sara and Maria Clara), I am currently a Professor in the Department of Biomolecular Sciences at the School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (DCBm-FCFRP-USP). I am affiliated with the Graduate Program in Biochemistry at FMRP/USP and the Graduate Program in Evolutionary Genetics and Molecular Biology at UFSCar (PPGGEv/UFSCar), teaching courses in biomolecules, protein-protein interactions, and CRISPR-Cas.Our research group focuses on protein metabolism, specifically on the functional characterization of the Ubiquitin-Proteasome System (UPS) in *Leishmania infantum*. We are working on ongoing FAPESP PI and CNPq Universal projects aimed at understanding this system to identify pharmacological targets for the treatment of leishmaniasis. (Source: Lattes Curriculum)
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The ubiquitin proteasome system (UPS) is primarily responsible for intracellular proteolysis in eukaryotes, consisting of enzymes E1 (ubiquitin-activating enzyme), E2 (ubiquitin-carrying enzyme) and E3 (ubiquitin-ligase) that promote the ubiquitination of protein substrates and the proteasome, a proteolytic macrostructure responsible for the degradation of ubiquitinated targets. In parasi…
The ubiquitin proteasome system (UPS) is responsible for the most of intracellular proteolysis in eukaryotes and the ubiquitination process occurs through the action of three enzymes: E1 (ubiquitin-activating enzyme), E2 (ubiquitin-carrying enzyme) and E3 (ubiquitin-ligases) that play a key role in this process, recognizing and transferring ubiquitin to its substrate. These ubiquitinated …
Fbxo7 is one of the 69 human F-box proteins, which interacts with SKP, Cullin and RBX to form the largest family of ubiquitin-ligases known as SCF-type E3 ubiquitin ligases. In addition to the F-box domain of interaction with SKP1, the Fbxl17 contains the LRR domain (Leucine Rich Repeat) which interacts with its substrates. The FBXL17 gene is recurrently disrupted by rearrangements in the…
The CoC / CCBS, considering the specificities of the Areas (Biological and Health) that make up the academic, research and extension structure of CCBS / UFSCar, following the guidelines of FAPESP, guided the application of RTI-FAPESP resources from the diagnosis of the current situation, in which the necessary actions were established to overcome the identified difficulties and to improve…
(Only some records are available in English at this moment)
Intracellular proteolysis in eukaryotes is primarily mediated by the Ubiquitin Proteasome System (UPS), which operates through the cascading action of three enzymes: E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3 (ubiquitin ligases). These enzymes are essential in this process as they recognize and transfer ubiquitin to target substrates. Intracellular proteol…
This scientific initiation scholarship quota within the PI-FAPESP proposal aims at the production of gene knockout mutants labeled with barcodes of genes related to the ubiquitination process by Cullin1-RING ubiquitin ligases (CRL1) of L. infantum. The characterization of the effects of gene knockouts in viable null mutants will be performed through comparative assays of isolated culture …
The genus Leishmania, composed of more than 20 species of parasites, is responsible for leishmaniasis, a parasitic disease transmitted by phlebotomine sandflies. Leishmaniasis can manifest in cutaneous forms (localized cutaneous, mucocutaneous, diffuse cutaneous, or disseminated) or visceral form (VL), the latter of which can be fatal if untreated. The global impact of leishmaniasis is su…
The genus Leishmania, composed of over 20 species of parasites, is responsible for leishmaniasis, a parasitic disease transmitted by sandfly vectors. Leishmaniasis can manifest in cutaneous forms (localized, mucocutaneous, diffuse, or disseminated) or visceral form (VL), the latter being potentially fatal if left untreated. The global impact of leishmaniasis is substantial, with millions …
(Only some records are available in English at this moment)
The ubiquitin proteasome system (UPS) is responsible for the most of intracellular proteolysis in eukaryotes and the ubiquitination process occurs through the action of three enzymes: E1(ubiquitin-activating enzyme), E2 (ubiquitin-carrying enzyme) and E3 (ubiquitin-ligases) that play a key role in this process, recognizing and transferring ubiquitin to its substrate. In parasitic protozoa…
Fbxo7 is an unusual protein which has been found to be associated with two major human diseases, cancer and Parkinson's disease (PD). Fbxo7 is one of the 69 human F-box proteins that serve as specificity factors for the largest family of ubiquitin-ligases known as SCF-type E3 ubiquitin ligases. These modular, multi-subunited holoenzymes are composed of S-phase-kinase associated protein 1…
| 1 / 1 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 13 / 12 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 23 / 22 | All research grants and scholarships |
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CV Lattes
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