Lucas Pires Guarnier

Graduated in Biotechnology from the Federal University of Grande Dourados (FCBA/UFGD) in 2018, I obtained a Masters degree in Health Sciences from the Graduate Program in Health Sciences at the Faculty of Health Sciences (FCS) of the same institution in 2020. I am currently enrolled in the PhD program in Genetics at the Faculty of Medicine of Ribeirão Preto (FMRP) at the University of São Paulo (USP), where I am a research fellow supported by a grant from the São Paulo Research Foundation (FAPESP). My doctoral research focuses on developing a hepatic steatosis model using spheroids of hepatocyte-like cells (HLCs) differentiated from induced pluripotent stem cells (iPSCs). This model has potential preclinical applications for drug screening based on plant extracts (medicinal plants) and cell therapy. The experimental part of the research is conducted in collaboration with the Liver Study Group (GEF) at the Precision Medicine Research Center (CPMP) of the Federal University of Rio de Janeiro (UFRJ). During my masters studies, I focused on preclinical testing of plant extracts with potential pharmacological effects for the treatment of cardiovascular diseases. In this context, I standardized an experimental model of atherosclerosis and hepatorenal impairments in Wistar rats. My research trajectory is marked by extensive experience in various areas, including laboratory animal handling, conducting antioxidant assays, performing vascular/renal reactivity procedures in mesenteric bed and isolated kidneys, as well as isolating and culturing mesenchymal stromal cells (MSC) from adipose tissue. (Source: Lattes Curriculum)