Abstract
Colorectal cancer (CRC) is one of the most common cancers and it represents about 10% of incidence and 9.4% of global cancer mortality, according to data released in 2020. The progress in treatment of CRC with chemotherapeutics drugs in the last 70 years was very limited, and the therapy with 5-fluorouracil still represents the bases of chemotherapy in many clinical protocols, including t…