Abstract
Inflammatory bowel disease (IBD) is a term used to describe prolonged inflammation of the gastrointestinal tract, including Crohn's Disease (CD) and Ulcerative Colitis. Ulcerative colitis affects enteric neurons and causes continuous mucosal inflammation, extending from the rectum to the proximal colon. The P2X7 receptor (P2X7R) is activated by increased levels of extracellular ATP in int…