Abstract
Na+/glucose cotransporter type 2 inhibitors (iSGLT2), also known as gliflozins, confer cardiorenal benefits, the precise mechanisms of which remain incompletely understood. Originally developed for treating type 2 diabetes mellitus (T2D), it was unexpectedly observed that these drugs reduce hospitalizations for heart failure (HF) and mortality from cardiovascular causes, irrespective of a…