CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. Instituto de Biociências, Letras e Ciências Exatas (IBILCE) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor at the Institute of Biosciences, Letters and Exact Sciences of São Paulo State University (UNESP) , where she has been a professor since 1996. Graduated with a Bachelor's degree in Biological Sciences (1989), master's degree in the Postgraduate Program in Cellular and Structural Biology of the State University of Campinas (1992), in the area of #8203;#8203;Comparative Spermatogenesis, and doctorate in the Cellular and Molecular Biology Program of the Ribeirão Preto School of Medicine of the University of São Paulo - FMPR/USP (1998), with the theme Extracellular Matrix and Protein Renewal in Ocular Tissues. Postdoctoral internship at FMRP-USP, in the area of #8203;#8203;Stem Cell Biology. Professor of Cell Biology, Embryology and Reproductive Biology at the Undergraduate and Graduate levels. Professor at Postgraduate Program in Biosciences (IBILCE/UNESP), beeing Coordinator (2020 - 2021) and currently serves Vice-Coordinator. Responsible for the Reproductive Histophysiology Research Laboratory (IBILCE/UNESP). Research interest in effects on the reproductive organs and reproductive function caused by metabolic disorders such as diabetes and obesity, exposure to endocrine disruptors or different nutritional environments. Other research topic that peak my interest include investiigations on the mechanisms involved in the development of prostate cancer, under the above-mentioned conditions, and prospecting studies of possible chemoprotectants for this disease. Affiliated with the Brazilian Society of Cell Biology and the American Society for Cell Biology. Also interest in area of #8203;#8203;Laboratory Animal Science and coordinated the Ethics Committee on the Use of Animals at IBILCE - UNESP (2008-2015). (Source: Lattes Curriculum)
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The type and amount of dietary lipids can differentially affect the prostate and promote the development of prostate cancer (PCa). The protective role initially attributed to polyunsaturated fatty acids (PUFAs) - eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) - in PCa has been questioned in recent studies. We have observed a variable action of DHA on the proliferation of non-t…
This study compares the impact of obesogenic environment (OE) in six different periods of development on sperm parameters and the testicular structure of adult rats and their correlations with sex steroid and metabolic scenario. Wistar rats were exposed to OE in gestation (O1), gestation/lactation (O2), from weaning to adulthood (O3), from lactation to adulthood (O4), from gestation to se…
Experimental evidence indicates that diabetes leads to atrophy,proliferation and cell death imbalance and increase incidence of malignantand pre-malignant lesions in the prostate. The low androgen levels and changes in insulin signaling have been implicated in these responses, but the role of oxidative stress should be further clarified. The neurohormonemelatonin has been widely used in t…
(Only some records are available in English at this moment)
Prostate Cancer (PCa) is a major public health problem, especially castration-resistant cancer (CRPC), whose treatment is still challenging. Experimental evidence indicates that consumption of the omega-3 (É-3) polyunsaturated fatty acid - docosahexaenoic acid (DHA) - reduces the risk of PCa, but this issue is still controversial in epidemiological studies. We have found that DHA delays t…
The modulation of autophagy may be an adjuvant in therapies for prostate cancer treatment. However, its role in cancer is complex and context-dependent, as autophagy can acts as a tumor suppressor in the early stages of tumor development or favors tumor progression in established or advanced tumors. Docosahexaenoic acid (DHA) is a polyunsaturated fatty acid that affects apoptosis in prost…
Prostate cancer (PCa) is one of the leading causes of death in men by cancer-related cases. Inflammation and diet directly affect the risk of developing PCa. Several reports show that docosahexaenoic acid, an omega-3 fatty acid, displays an anti-tumor effect on PCa, however, more studies are needed to clarify its effects on tumor progression. Annexin A1 (ANXA1), an anti-inflammatory prote…
(Only some records are available in English at this moment)
Phthalates are endocrine active substances (EAS) widely used as plasticizer. Among the EAS, di-ethylhexyl phthalate (DEHP) is a very relevant endocrine disruptor (ED) for human exposure. After absorption DEHP is rapidly hydrolyzed in mono-2-ethylhexyl phthalate (MEHP), its active metabolite. Many studies confirmed the reprotoxic effects of MEHP exposure on males, such as perturbations in …
Experimental diabetes leads to drastic prostatic atrophy and impairment of secretory capacity. This damage is associated with the imbalance in epithelial kinetics, remodeling of the extracellular matrix and morphofunctional changes in prostatic stromal cells. There was also increase incidence of intraepithelial neoplasia (PIN) and incidence of malignancies in the prostate after three mont…
| 8 / 5 | Completed research grants |
| 28 / 23 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 38 / 30 | All research grants and scholarships |
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