CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
After graduating as a pharmacist at the Faculty of Pharmaceutical Sciences of Ribeirão Preto - University of São Paulo in 2002, the researcher enrolled an MSc in Pharmaceutical Sciences (2006), a PhD in Sciences (2010) and a Post-doctoral fellowship in Medicinal Chemistry (2012) at the same institution. After working as an Assistant Professor at the College of Pharmacy at the Federal University of Rio Grande do Sul from 2012-2015, he moved to the Faculty of Pharmaceutical Sciences at the University of Campinas UNICAMP, were it currently works as an Associate Professor in Medicinal Chemistry. Expertise: Design and synthesis of bioactive compounds. Organic synthesis and structural characterization. Molecular modeling - bioinformatics, molecular docking, pharmacophore modeling, virtual screening and molecular dynamics. (Source: Lattes Curriculum)
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For more than 40 years, the fluid mosaic model of cellular membranes have supported our vision of an inert lipid bilayer containing membrane protein receptors that are randomly hit by extracellular molecules to trigger intracellular signaling events. However, the notion that compartmentalized cholesterol- and sphingomyelin-rich membrane microdomains known as lipid rafts spatially arrange …
Prostate cancer represents the second most frequent type of cancer among men, with the development of metastases being the main cause of death associated with it. In this sense, the involvement of adjacent lymph nodes, liver, lungs and, especially, bones is common, with 9 out of 10 patients with metastatic prostate cancer manifesting bone tissue involvement. Although androgen castration t…
Prostate cancer is the second most common cancer among men, with the development of metastases being the main cause of death associated with it. In this sense, the involvement of adjacent lymph nodes, liver, lungs and, especially, bones is common, with 9 out of 10 patients with metastatic prostate cancer manifesting bone tissue involvement. Although androgenic castration therapy is effect…
Antitumor phospholipids are synthetic analogues of endogenous phosphatidylcholines with a remarkable ability: inducing the selective apoptosis of exponentially growing tumor cells. Concerning their mechanism of action, one hypothesis points to the inhibition of the enzyme cytidine triphosphate (CTP):phosphocholine cytidylyltransferase (CCT) as a key event related to the antitumor actions …
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Acute myeloid leukemia (AML) is a hematologic cancer with poor prognosis, commonly presenting resistance to available treatments. Phospholipid metabolism is severely altered in AML cells and appears to be closely related to malignancy and resistance, suggesting the existence of therapeutic opportunities in the inhibition of participating enzymes. One of these enzymes is acid ceramidase (a…
Acute Myeloid Leukemia (AML) is a blood and bone marrow malignancy that causes the proliferation of abnormal blood cells known as blasts. AML has a poor prognosis, with a 5-year survival around 28% or lower for patients older than 64 years. AML is also an extremely heterogeneous disease and even the most frequently mutated gene, the FLT3, only accounts for 30% of the cases. Therefore, the…
| 1 / 1 | Completed research grants |
| 6 / 5 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 9 / 8 | All research grants and scholarships |
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