CV Lattes
ORCID
Abstract
DNA damage activates pleiotropic cellular responses such as cell cycle arrest and senescence, but can also induce an inflammatory interferon response, which is an anti-viral pathway activated by the presence of DNA in the cytoplasm. We have identified PARP9 and DTX3L, two proteins that form a heterodimer in cells and are expressed from a shared interferon-responsive promoter, in a screen …