Abstract
In a directly isolated rat atrium, 6-nitrodopamine has a potent positive chronotropic effect, being more potent than the classic catecholamines norepinephrine, adrenaline and dopamine. Another interesting feature of 6-nitrodopamine (6-ND) is its ability to synergize with classical catecholamines. In anesthetized rats, 6-ND has a potent positive chronotropic effect, however this positive c…