CV Lattes
ORCID
Abstract
Chaperone-mediated autophagy (CMA) is a selective process of intracellular protein degradation, in which a pentapeptide motif similar to KFERQ is recognized by cytosolic chaperones, that direct the substrate to the lysosomal surface, where the LAMP2A receptor allows cargo translocation across the lysosomal membrane. CMA plays a crucial role in maintaining cellular homeostasis, regulating …