Abstract
Among the various factors that contribute to the evolution of CKD, focal segmental glomerulosclerosis (FSGS) gains relevance, while the glomerular fibrotic lesion corroborates the loss of renal function. Studies demonstrate that the transcription factor Early Growth Response (Egr-1) and mitogen-activated protein kinases (MAPK) are associated with kidney diseases, including glomerulosclero…