Abstract
The aim of this study will be to clinically evaluate teeth with pulpal necrosis and apical periodontitis (AP), antimicrobial activity, levels of inflammatory markers (IL-1B and TNF-a), and metalloproteinase (MMPs) before and after the use of intracanal medications based on chlorhexidine. For this purpose, 24 teeth from patients with primary endodontic infection and AP will beselected. The…