Abstract
New imidazopyridine (imidazo[1,2-a]pyridine and imidazo[1,2-c]pyrimidines) derivatives were synthesized and showed potent biological activity against parasite cultures (T. cruzi and T. brucei), low cytotoxicity and high metabolic stability. It was observed that an imidazo[1,2-c]pyrimidine derivative exhibited excellent plasma exposure upon oral administration in rats, however, the low sol…