Abstract
The purinergic system is important and plays a fundamental role in the vascular system. It is an extracellular signaling system composed of nucleotides (ATP, ADP, and UDP, for example), nucleosides (adenosine), receptors (P1 and P2), and ectonucleotidases (enzymes). Nucleotides and nucleosides present in the circulation are directly linked to the maintenance and control of vascular tone. …