Abstract
Among the natural products, polyketides and non-ribosomal peptides are very diverse compounds synthesized by giant enzymes, polyketide synthases (PKSs), and non-ribosomal peptide synthases (NRPS), respectively. Through various iterative elongation cycles, PKSs catalyze the sequential condensation of two or three carbon units to a growing acyl chain covalently tethered to a carrier domain …