Abstract
Periodic Syndromes Associated with Cryopyrin (CAPS) are monogenic inflammasomopathies, meaning systemic autoinflammatory diseases caused by gain-of-function mutations in the NLRP3 gene. This gene encodes the NLRP3 inflammasome receptor, and its mutations lead to hyperactivation of the complex and increased production of inflammatory cytokines IL-1¿ and/or IL-18, as well as the induction o…