Abstract
Ulcerative colitis (UC) compromises the enteric nervous system (ENS), affecting intestinal motility. The purinergic P2X7 receptor is involved in inflammatory and apoptotic pathways during UC. Female sex hormones, such as estrogen, can modulate these inflammatory responses, primarily through estrogen receptors ER¿ and ER¿. This study aims to investigate the effects of P2X7 receptor deficie…