Abstract
MicroRNAs are small non-coding molecules that regulate gene expression through mRNA cleavage or translational repression, influencing various biological processes, including apoptosis. Alterations in miRNA expression are associated with hyperproliferative diseases, such as chronic lymphocytic leukemia (CLL), in which miR-15a and miR-16-1 - negative regulators of Bcl-2 - show reduced expre…