Abstract
The oligopeptidase neurolysin (EC 3.4.24.16; Nln) was first identified in synaptic membranes of the rat brain, participating ubiquitously in the catabolism of bioactive peptides such as neurotensin and bradykinin. Recently, it was shown that knockout mice for Nln (KO) present an increase in glucose uptake, insulin sensitivity and gluconeogenesis. The liver of KO animals have increased mRN…