CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas Bacharelado from Universidade Estadual de Ponta Grossa (2007), master's at Microbiology from Universidade de São Paulo (2011) and doctorate at TOXINOLOGIA from Instituto Butantan (2015). Has experience in Microbiology, focusing on Microbiology, acting on the following subjects: escherichia coli, ehec, controle biológico, epec and endofíticos. (Source: Lattes Curriculum)
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Monoclonal antibodies (mAbs) have proven efficacy in the treatment of cancer, chronic and infectious diseases. Most mAbs available on the market are complete IgGs that use eukaryotic cells for their production, requiring more time and resources. It is worth noting that the nature of some antigens can make obtaining conventional mAbs challenging and costly.A promising alternative to the tr…
Recently, the Antibody Development Center at the Butantan Institute began implementing the Center of Nanobody Discovery, led by researchers Daniela Luz, Debora Moretti and Roxane Piazza. This center aims to implement a platform for the selection of therapeutic nanobodies and detection against different antigens, from poisons to infectious and tumor targets with the purpose of generating m…
Despite significant advances in research, cancer still poses a threat to global health. This disease chronicity and constant antigenic stimulation leads to the differentiation of CD8+ T cells into populations with altered effector functions, a unique epigenetic profile, and high levels of expression of multiple inhibitory receptors. These negative regulatory receptors have the function of…
Antibodies are glycoproteins produced by plasma cells, the IgG the most commonly used in antibody therapy. Hybridoma technology has enabled the production of monoclonal antibodies (mAbs) derived from laboratory animals. Methods as phage display allowed the development of recombinant antibody fragments (rAbs), with in vitro immunological repertoires without direct immunization of living ho…
Despite significant advances in research, cancer still represents a threat to global health. The chronicity of this disease and constant antigenic stimulation leads to the differentiation of CD8+ T cells into populations with altered effector functions, a unique epigenetic profile, and high levels of expression of multiple inhibitory receptors. Such negative regulatory receptors have the …
Dengue is a neglected viral disease that infects and kills thousands of people each year. In areas where arboviruses co-circulate, the differential diagnosis of the disease is challenging due to the possibility of serum antibody cross-reactivity to other flaviviruses. This scenario is exacerbated by the lack of safe and effective vaccines widely available to the general population. It is …
Among the diarrheagenic Escherichia colipathotypes, Shiga toxin-producing E. coli (STEC), and its enterohemorrhagic subgroup (EHEC), stand out for their potential to cause serious diseases, such as hemorrhagic colitis, which affects up to 90% of infected patients, and hemolytic uremic syndrome, which occurs in 5 to 15% of individuals. Such complications occur due to the production of its …
(Only some records are available in English at this moment)
Shiga toxins (Stx) produced by Shiga toxin-producing Escherichia coli (STEC) are the most potent cytotoxins of type AB5, found as two distinct types (Stx1 and Stx2) and subtypes, causing hemolytic uremic syndrome (HUS), characterized by thrombocytopenia, hemolytic anemia, and renal failure, which can cause death. The most indicated treatment against Stx-mediated HUS is the neutralization …
Rheumatoid arthritis (RA) is characterized by chronic infiltration of immune cells into the synovial membrane, leading to progressive destruction of articular cartilage and bone. The most notable success in treating rheumatoid arthritis has been the introduction of Tumor Necrosis Factor (TNF) inhibitors. Anti-TNF agents have radically changed the prognosis of many patients with RA, provid…
Diarrheal disease is one of the main public health problems worldwide, causing about 1.5 million deaths annually in children under five years of age, and about 30 to 40% of episodes of acute diarrhea in the world are caused by diarrheagenic Escherichia coli, with emphasis on the pathotype responsible for acute diarrhea/traveller's diarrhea, enterotoxigenic E. coli (ETEC). ETEC produces th…
(Only some records are available in English at this moment)
Despite advances in research, skin cancer remains the most common type of tumor in Brazil. Nivolumab, an anti-PD-1 monoclonal antibody, has shown success in the treatment of melanoma. This antibody blocks the immune checkpoint PD-1, a molecular receptor expressed by immune cells that when interacts with their ligands leads these cells to an exhaustion state, in which they present altered …
Shiga toxins (Stx), produced by Escherichia coli (STEC), are potent AB5 cytotoxins associated with hemolytic uremic syndrome (HUS), a severe condition characterized by thrombocytopenia, hemolytic anemia, and renal failure, which can be fatal. Currently, no effective therapies exist for Stx-mediated HUS, and antibiotic treatment, particularly quinolones, is not recommended as it induces to…
This research focuses on immune checkpoints, crucial regulators of T lymphocyte activity. Immune checkpoint discovery began in the 1990s with proteins like PD-1 and CTLA-4. TIM-3 is also a checkpoint associated with tumor and virus evasion and its blockade by monoclonal antibodies has proved capable of being used as a target for anti-tumor therapies. Immunotherapy, utilizing monoclonal an…
Shiga toxin-producing Escherichia coli is responsible for hemorrhagic colitis and hemolytic-uremic syndrome, which aggravates the condition of the infected patients. The diagnosis of this pathogen is not included in routine laboratories in developing countries. The development of tools for detecting these toxins becomes very relevant to their diagnosis. Antibodies have proven to be an exc…
| 1 / 1 | Ongoing grants |
| 3 / 3 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 8 / 7 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 20 / 19 | All research grants and scholarships |
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