CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Medicina from Universidade de São Paulo (1972), master's at Pediatria Ribeirão Preto from Universidade de São Paulo (1978) and ph.d. at Pediatria Ribeirão Preto from Universidade de São Paulo (1983). He is currently full professor at Universidade de São Paulo. Has experience in Medicine, focusing on Child Health, acting on the following subjects: acute lymphoblastic leukemia, criança, childhood, pcr and children. (Source: Lattes Curriculum)
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Currently, even with intensive multimodal treatment, 20% of children and adolescents with cancer will still die due to disease and over 40% of survivors develop sequelae that affect the adult quality of life. Therefore, more effective and safer treatment options for children with cancer are still needed to increase cure rates, decrease toxicity and to minimize the risk of long term effect…
Glioblastoma is one of the most aggressive human cancers. Despite current advances in multimodality therapies, such as surgery, radiotherapy and chemotherapy, the outcome for patients with this neoplasia remains fatal. Thus, novel effective treatment regimens are urgently needed.Tetra-O-methyl nordihydroguaiaretic acid (M4N), a global transcription inhibitor of Sp1-regulated genes, has sh…
Acute Lymphoblastic Leukemia (ALL) is the most common hematologic malignancy in childhood. It's a heterogeneous disease and despite advances in treatment approximately 20% of patients have relapse or death indicating the need for differentiated therapies for this group. The analysis of genetic and epigenetic abnormalities may enable a more accurate diagnosis and the development of specifi…
(Only some records are available in English at this moment)
Medulloblastoma (MB) is the malignant neoplasm of the central nervous system most commonly diagnosed in pediatric patients. MB is assigned into 4 molecular subgroups: WNT, SHH, MB of Group 3 and Group 4. MB Group 3 and 4 are molecularly poorly understood and presents a high rate of metastasis and relapse. Trought in silico analysis we showed that in Group 3 and 4 MB, there is an overexpre…
(Only some records are available in English at this moment)
Ependymoma (EPN) accounts for a substantial number of childhood deaths and over 70% of children presenting with EPN will relapse and eventually die. This tumor is a heterogeneous disease, which has been classified into nine molecular subgroups. Importantly, children with the most common type of ependymoma, posterior fossa Group A (PFA1), relapse more frequently and experience more invasiv…
Ependymoma (EPN) is the third most frequent brain tumor in children. This tumor is a heterogeneous disease, which can be classified into nine molecular subgroups. The ST-EPN-YAP1 and ST-EPN-RELA subgroups affect children, with RELA-positive subgroup specifically associated with poor prognosis and resistance to therapy. DNA methylation, an epigenetic alteration, has been shown to be an imp…
Ependymoma (EPN) is the third most frequent brain tumor in children. This tumor is a heterogeneous disease, which can be classified in nine molecular subgroups. The subgroups ST-EPN-YAP1, ST-EPN-RELA and FP-EPN-A are more frequent in children. ST-EPN-RELA and FP-EPN-A subgroups are associated with poor prognosis and resistance to therapy. Our project is focused on understanding specifical…
(Only some records are available in English at this moment)
| 10 / 6 | Completed research grants |
| 35 / 31 | Completed scholarships in Brazil |
| 9 / 9 | Completed scholarships abroad |
| 54 / 46 | All research grants and scholarships |
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