Leonardo Yuji Tanaka

• Abstract

  The study concerning on how cells adapt to distinct mechanical forces, translating physical stimulus in to chemical signals, is such a remarkable issue from mechanobiology, with direct implications on pathophysiology, particularly cardiovascular diseases. Growing evidences point out that redox pathways of cell signaling are fundamental mediators of mechanoadaptive responses. However, the …

  Subcellular mechanisms underlying the convergence between redox and mechanic homeostasis on vascular regulation, AP.JP

• Abstract

  The electromagnetic force is one of the fundamental forces of nature, in this way, it participates in the reflections between tiny individuals and the large-scale behavior of all matter in the universe. Magnetic field (MF) effects have been reported to influence the biological behavior in several cell types during their evolutionary process, participating in homeostatic responses, patholo…

  Effect of magnetic field stimulation on vascular structure and function: potential mechanisms of redox regulation, BP.IC
• Subcellular mechanisms underlying the convergence between redox and mechanic homeostasis on vascular regulation, BP.JP
• Subcellular mechanisms underlying the convergence between redox and mechanic homeostasis on vascular regulation, BP.JP

(Only some records are available in English at this moment)

• Abstract

  While vascular remodeling is a key determinant of vascular lumen in (patho)physiological situations, its mediators remain poorly understood. Recently, we showed that the endoplasmic reticulum redox chaperone protein disulfide isomerase-A1 (PDI) is markedly upregulated during vascular repair to injury, while its externalized pool (peri/epicellular PDI=pecPDI) counteracts constrictive remod…

  Characterization and mechanisms of microRNA-mediated paracrine signaling involving protein disulfide isomerase-dependent mechano-adaptation in vascular cells, BE.EP.PD