Débora Simões de Almeida Colombari

• American Physiology Summit, AR.EXT

• Abstract

  Obesity and hypertension are the leading cause of death in the world. Obesity and overweight contribute to elevated blood pressure in many patients with essential hypertension. Experimental and clinical studies indicate that visceral obesity induces hypertension by increasing renal sodium reabsorption through multiple mechanisms including activation of the sympathetic nervous system (SNS)…

  Experimental pathophysiology: role of central mechanisms of the cardiovascular and respiratory control changes induced by experimental hypertension and obesity, AP.TEM
• Experimental Biology 2015, AR.EXT

(Only some records are available in English at this moment)

• Abstract

  Overweight and obesity are major risk factors for many chronic diseases, including cardiovascular diseases such as hypertension. There is a high prevalence of obesity and hypertension in postmenopausal women. Women also ingest more sodium than men, correlating with higher blood pressure (BP) values. In this study, using an animal model, we will verify if obese female rats with free access…

  Cardiovascular changes to water deprivation in rats fed a high-fat diet: possible mechanisms, BP.IC

• Abstract

  During obesity, there is an increase in the renin-angiotensin system (RAS) activity. Thus, a greater RAS activation, and the consequent increased levels of peripheral angiotensin II (ANG II), can activate forebrain areas of the central nervous system (CNS) free of the blood brain barrier located in the lamina terminalis, and rich in ANG II receptors, such as the subfornical organ (SFO). W…

  Mechanisms involved in the cardiovascular and hydroelectrolytic changes induced by central Angiotensin II and osmoreceptors in rats fed with a high-fat diet, BP.DR

• Abstract

  In recent decades obesity has become a worldwide epidemic. Excess adipose tissue favors the development of associated diseases such as high blood pressure and also causes changes in hydroelectrolytic balance, which may also affect blood pressure. Data from the literature show that obesity activates the renin-angiotensin system (RAS) and we have recently demonstrated that rats fed a high-f…

  Cardiovascular changes and neuronal activation induced by furosemide associated with captopril in rats fed with a high-fat diet, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Obesity is defined as the excessive accumulation of fat that causes damage to the health of the individual. In recent decades, some factors have been attributed to weight gain, such as increased intake of highly energetic foods that are high in fat and an increase in physical inactivity. High-fat diet induced-obesity leads to a greater activation of the renin-angiotensin system including …

  Effect of acute optogenetic and chronic chemogenetic activation of AT1a receptors in paraventricular nucleus neurons on energy metabolism in high-fat diet animals, BE.EP.DR

• Abstract

  Obesity is associated with the development of pathologies including cardiovascular diseases, hormonal and respiratory dysfunctions. Recently, studies have suggested that gestational obesity may also have an impact on the development of pathologies in offspring. The cardiorespiratory changes observed in the offspring promoted by maternal obesity, as well as the neural mechanisms involved, …

  Participation of respiratory oscillators on the modulation of RVLM presympathetic neurons in offspring from obese dams, BE.EP.PD

• Abstract

  The nucleus of the solitary tract (NTS) is the primary synaptic site of different visceral afferents, including the baroreceptors. A functional cholinergic system has been described in the NTS. Microinjection of acetylcholine (ACh) or the muscarinic agonist carbachol into the intermediate NTS (iNTS) of anaesthetized or awake rats induces dose-dependent baroreflex-like hypotensive and brad…

  Cholinergic mechanisms of the intermediate nucleus of the solitary tract involved in the cardiorespiratory responses of the Hering-Breuer reflex, BE.EP.DR

(Only some records are available in English at this moment)