CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Associate Professor from Department of Biological Sciences, Federal University of São Paulo - UNIFESP. Visiting Researcher at Institute Aggeu Magalhães - Oswaldo Cruz Foundation - FIOCRUZ (2019-2020). Postdoctoral at the Institute of Biomedical Sciences-I (ICB-I) of the University of São Paulo (USP) and University of Alabama at Birmingham (UAB) in 2012-2013. PhD in Human Physiology from USP (ICB-I, 2008). Conducted the sandwich doctoral program at Baylor College of Medicine, Houston, Texas, USA in 2006-2007. Graduated in Biomedicine (1999-2002). Has experience in Physiology, focusing on biological rhythmicity, acting on the following subjects: neurophysiology, neuroendocrinology, CNS clock genes and peripheral tissues. (Source: Lattes Curriculum)
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Melatonin, the mammalian pineal gland hormone, synthesized during the dark phase, shows a circadian and seasonal rhythm. Its synthesis is synchronized to the light/dark cycle and to seasonal photoperiod informations through the year, which is transmitted to the gland through the retino-hypothalamic pathway. Melatonin synthesis is induced by norepinephrine release in the gland perivascular…
Our research group has being studying the modulation events of melatonin synthesis by peptidergic systems as insulin and leptin, as well as the actions of melatonin as a zeitgeber (time-keeper) to the heart. We have shown that insulin potentiates melatonin synthesis in the pineal gland due to an increase in the activities of the main enzymes involved on the synthesis of the pineal hormone…
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