Abstract
HIG2 (hypoxia inducible gene 2) is a gene that encodes a protein that is called HIG2. This protein is able to bind to Frizzled receptors and activate the Wnt/beta-catenin pathway. Recent data from our group has shown differential expression of the gene HIG2 in peripheral blood mononuclear cells (PBMC) and specially in naïve CD4+ T cells isolated from healthy individuals, but not in memory…