graduate at Bacharelado Ciências Biológicas from Instituto de Biociências Letras e Ciências Exata (1991), master's at Biochemistry from Universidade Estadual de Campinas (1994) and ph.d. at Biochemistry from Universidade Estadual de Campinas (1999). Has experience in Physiology, acting on the following subjects: hemoglobina, oxidação, eritrócito, insulin and obesidade. (Source: Lattes Curriculum)
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Faculty of Applied Sciences (FCA) of the State University of Campinas (Unicamp) has developed, since its implementation in 2009, important activities in teaching, research and extension. Completing the teaching-research-extension triad, with regard to research, and consequently part of the extension, the organization of the FCA takes the form of Centers and Laboratories. With this structu…
Numerous diseases, in which the inflammatory process plays an important role in pathophysiology, have a high prevalence in the population, such as obesity, diabetes, cardiovascular diseases, cancer, and inflammatory bowel diseases. The immune system utilizes inflammatory processes to act against infectious agents, but excessive activation can have consequences for the organism. The alpha7…
Neural progenitor cells (NPCs) can differentiate into neurons, astrocytes, and oligodendrocytes. Differentiation and proliferation are regulated by various cell communication factors (e.g., Notch/Hes1) and neuroregulatory transcription factors (bHLH, including Mash1 and Ngn3). We have recently shown that TNF± and reactive oxygen species can also modulate these factors, suggesting that the…
(Only some records are available in English at this moment)
Faculty of Applied Sciences (FCA) of the State University of Campinas (Unicamp) has developed, since its implementation in 2009, important activities in teaching, research and extension.Completing the teaching-research-extension triad, with regard to research, and consequently part of the extension, the organization of the FCA takes the form of Centers and Laboratories.With this structure…
Since your implementation in 2009, the Faculty of Applied Sciences (FCA) of the State University of Campinas (Unicamp) has developed important activities in education, research and extension in your interdisciplinary pedagogical project. Completing the education-research-extension triad, with regard to research, and consequently part of extension, the organization of FCA takes the form of…
The fundamental cause of obesity is the imbalance between the ingested calories and the energy expenditure, and the main regulator of this energy balance is the hypothalamus. Nicotinic-type cholinergic receptors play an important role in this process, as they are able to alter neuronal excitability, favoring the neurotransmitters secretion. The nicotinic acetylcholine ±7 cholinergic recep…
(Only some records are available in English at this moment)
The hypothalamus is one of the main regulatory centers of energy homeostasis and metabolic disorders such as obesity are related to hypothalamic signaling damage. In this sense, the alpha 7 subunit of the nicotinic cholinergic receptor (±7nAChR) expressed in hypothalamic neurons seems to modulate the expression of neuropeptides that favor negative energy balance, such as pro-opiomelanocor…
Despite all the technical scientific advances in the field of Oncology recorded in recent years, Cancer is still a high incidence disease and the second leading cause of mortality worldwide. By 2030, the expected global burden is 21.4 million new Cancer cases and 13.2 million Cancer deaths. Lung and Breast Cancers make up the majority of Cancers in men and women, with the exception of non…
The hypothalamus express different neuropeptides that control different aspects of body homeostasis. The arcuate nucleus is a hypothalamic region composed of two populations of neurons involved with energy homeostasis: orexigenic (NPY/AGRP), which stimulate food intake and anorectic (POMC/CART), which inhibit food intake. Leptin, one of the signaling hormones of these neurons, acts throug…
The cholinergic system is widely expressed in the body, highlighting the role of alpha7nAChR receptor in the systemic anti-inflammatory response. However, recent studies have shown that the nicotinic receptor, expressed in hypothalamic neurons, contributes to the maintenance of energy homeostasis. In this sense, the aim of this study will be to evaluate the role of the alpha7nAChR recepto…
(Only some records are available in English at this moment)
The hypothalamus is one of the main regulatory centers for energy homeostasis and this control is profoundly impaired by inflammatory processes that damage hypothalamic signaling, which can result in the development of metabolic disorders. The lipid species that accumulate under these conditions, such as ceramides or their metabolites, are among the most detailed because they can lead to …
Studies showed that short-term consumption of a diet rich in saturated fatty acids activates inflammatory pathways in the hypothalamus, supporting the idea that inflammatory processes have a fundamental role in the development of metabolic disorders that are associated with hypothalamic activity. The lipids species that accumulate under these conditions, sphingolipids such as ceramide or …
The cholinergic system presents a wide diffusion in the organism, while the alpha 7 nicotinic acetylcholine receptor subunit (a7nAChR) is most widely expressed. Recent studies have shown that ±7nAChR has an important role in energy homeostasis maintenance. This role is mediated by JAK2-STAT3 pathway activation but also it can be associated with its calcium-selective ionic channel function…
The control of the activity of the hypothalamic-pituitary-gonadal (HPG) axis is exerted by a complex network of metabolic and hormonal signals. The early activation of HPG axis promotes for example, the precocious onset of puberty, as observed in obesity. Moreover, the absence of leptin or signaling capability may also inhibit the development of puberty, lower expression of GnRH secretion…
The inflammatory process which contributes to the obesity setting has now widely being studied. The high consumption of saturated fat and pathogenic agents can lead to an increase in inflammatory cytokines through toll like receptor (TLR), interfering with the signaling pathway proteins as AMPK, ACC and mTOR, which are known to control the hypothalamic energy balance. The modulation of …
| 4 / 4 | Ongoing research grants |
| 15 / 9 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 23 / 17 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 48 / 36 | All research grants and scholarships |
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CV Lattes
ORCID