CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Farmácia - Análises Clínicas from Universidade Federal de Santa Catarina (2001), master's at General Pharmacology from Universidade Federal de Santa Catarina (2004) and doctorate at Biochemistry from Universidade Federal de São Paulo (2008). Has experience in Biochemistry, focusing on Metabolism and Bioenergetics, acting on the following subjects: camundongo, inflamação, diabetes, cininas and pleurisia. (Source: Lattes Curriculum)
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Energy metabolism is paramount for life and response to stress in eukaryotes, and mitochondria are key organelles not only for being the main site of ATP and intermediary metabolite synthesis, but also for acting as signaling platforms involved in the response to different stresses. Nutrient deprivation is one of the most ancient evolutionary pressures faced by living organisms and, in th…
Mitochondria are dynamic organelles that integrate metabolic cues and modulate their own activity with the aim of regulating the production of energy and metabolic intermediates, as well as the induction of systemic responses. Together, these factors are crucial to the maintenance of homeostasis under stressful situations. Calorie restriction is a nutritional intervention that increases t…
(Only some records are available in English at this moment)
CD36 is a scavenger receptor involved in physiological processes ranging from innate immune response to lipid metabolism. Experimental data obtained in vertebrates indicate that CD36 is directly involved in lipid absorption and determination of lipid droplet composition and organization within cells. However, the molecular mechanisms through which CD36 promotes its actions is not complete…
Lipid metabolism participates in almost every aspect of metazoan life, but, in spite of its centrality to life, topics such as the complete characterization of the lipid repertoire of organisms, the elucidation of how this repertoire is remodeled in response to specific exogenous or endogenous stimuli, as well as the identification of the molecular effectors involved in each situation are…
The endoplasmic reticulum (ER) UPR is an adaptive response of the organism that through specific molecular pathways acts to reestablish cell homeostasis in stressful situations. In a previous work by the group, it was observed that the deficiency of the lipase LIPL-5 caused changes in the C. elegans lipidome, increasing the amount of cardiolipins, coenzyme Q9 and some types of ceramide, s…
Calorie restriction (CR) is a nutritional intervention capable of affording a number of metabolic benefits to organisms that may lead to lifespan extension. In spite of being studied for more than 80 years, the mechanisms through which CR exerts its effects are not completely elucidated. Ubiquitin-proteasome system (UPS) is a proteolytic system through which intracellu…
Mitochondria are dynamic organelles that undergo fusion or fission depending on the cell metabolic need. It is well known that mitochondrial morphology is intimately linked to mitochondrial activity and thus is critical for homeostasis maintenance during metabolic fluctuations. Dietary restriction is a nutritional intervention that increases the longevity of a number of organisms, and par…
(Only some records are available in English at this moment)
The physical and functional interaction between mitochondria and Endoplasmic Reticulum (ER) is crucial for cellular response to stress, and profoundly impacts the activity of both organelles. During stressful situations, organisms activate adaptive responses, such as the unfolded protein response (UPR), in the attempt to restore homeostasis. Mitochondrial activity of Caenorhabditis elegan…
Calorie restriction (CR) is a nutritional intervention that has been shown to extend lifespan in a variety species and also to afford metabolic benefits. The mechanisms involved in these CR benefits are not fully elucidated. Data from our group demonstrated that Saccharomyces cerevisiae cells cultured under calorie restricted conditions apart from having a life span extension, showed incr…
| 6 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 5 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 15 / 12 | All research grants and scholarships |
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