Amanda Juliana Sales in research grants and scholarships supported by FAPESP.
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Ketamine has been widely studied as a drug with rapid and effective antidepressant action in resistant patients to the available conventional treatments. Recently, we have demonstrated that Cannabidiol (CBD), as well as ketamine, has a rapid and sustained antidepressive effect in different animal models. However, the mechanisms involved in this effect are not yet known. It has been assign…
Epigenetic mechanisms, such as DNA methylation (is regulated by DNMTs), are thought to play an important role in the neurobiology of depression. In this sense, we demonstrated that inhibitors DNA methylation have antidepressant-like effect in animals submitted to forced swimming test and tail suspension. Objectives: Whereas DNMTs inhibitors have different mechanism of action the conventio…
Recent evidences have suggested that nitric oxide (NO) might be involved on the neurobiology of depression, since the its synthesis inhibition induces antidepressant-like effects in animal models. The participation of specific brain regions and the molecular mechanisms involved in such effects remain to be investigated. Considering that intra-hippocampal injection of a preferential inhibi…
| 3 / 3 | Completed scholarships in Brazil |
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