Abstract
Chemotherapy agents 5- fluorouracil (5-FU), methotrexate (MTX) and melphalan are widely used in the treatment of malignant neoplasms and hematopoietic stem cell transplantation conditioning. These agents, however, induce intense production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), which in the oral mucosa, can lead to the development of oral mucositis. Oxidativ…