Abstract
This project aims at investigating the autophagic response of human glioma cell lines and human dermal fibroblasts in response to agents capable of inducing DNA damage. (AU)
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Alexandre Teixeira Vessoni
CV Lattes
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Post-doctoral research associate in the School of Medicine of the Washington University in Saint Louis (Missouri, USA), supported by Philip W. Majerus, M.D. fellowship. Develops a project focused on the following themes: human pluripotent stem cells, telomere biology and aging, under supervision of Professor Luis Francisco Zirnberger Batista. Graduated with a B.Sc. in Biological Sciences from the University of São Paulo (2008) and a PhD in Sciences (Microbiology) from the same university (2015; FAPESP scholarship). From August 2012 - July 2013, and from September 2014 - February 2015, I was awarded with the scholarships BEPE (FAPESP) and PDSE (CAPES), respectively, which supported me as a visiting grad student in the laboratory of Prof. Alysson Renato Muotri (University of California, San Diego, USA) to develop part of my PhD project. Has experience in cellular and molecular biology, focusing on: cell reprogramming, culture and differentiation of induced pluripotent stem cells into neurons, DNA repair, autophagy, oncogenes and cell plasticity. (Source: Lattes Curriculum)
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Scholarships in Brazil
- Autophagy analysis in response to agents capable of inducing DNA damage, BP.DD
- Autophagic and cell death analysis in cells proficient and deficient to DNA excision repair exposed to UVB light, BP.MS
Abstract
Autophagy is a process responsible for the degradation of deficient and/or obsolete proteins and cytoplasmic organelles, aiming at maintaining the cell homeostasis. Furthermore, deficiencies in the autophagic process can lead to elevated tumorigenesis rates, what makes this mechanism an interesting target for new cancer therapy drugs. This project aims for the study of the relationship be…
Scholarships abroad
- Use of IPS cell-derived neurons to study a possible role for autophagy in the neurodegenerative phenotype of Cockayne Syndrome, BE.EP.DD
Abstract
This project aims at studying a possible role for autophagy in the neurodegenerative phenotype observed in patients with Cockayne Syndrome. In order to do that, human skin fibroblasts from CS patients will be reprogrammed to a pluripotent state (iPS cells) and then, differentiated into neurons, thus, constituting a model to study the neurodegenerative phenotype observed in these patients.…
Total / Available in English
| 2 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 3 / 3 | All Scholarships |
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