Abstract
Male fertility is controlled by a combination of hormonal signals that control the Sertoli cell production of the necessary factors for spermatogenesis. FSH and testosterone are the main regulators of spermatogenesis. Depending on the maturation stage of the Sertoli cells, these hormones activate signaling pathways such as cAMP/PKA, ERK1/2 or PI3K/AKT. Members of the PI3K/AKT and cAMP cas…